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Faecalibacterium prausnitzii Induces an Anti-inflammatory Response and a Metabolic Reprogramming in Human Monocytes

Faecalibacterium prausnitzii strain EXL01 boosts efficacy of immune checkpoint inhibitors

Faecalibacteriumprausnitzii Is Associated With Clinical Response to Immune Checkpoint Inhibitors in Patients With Advanced Gastric Adenocarcinoma: Results of Microbiota Analysis of PRODIGE 59-FFCD 1707-DURIGAST Trial

Faecalibacterium prausnitzii induces an anti-inflammatory response and a metabolic reprogramming in human monocytes

Sokol, H ; Pigneur, B ; Watterlot, L ; Lakhdari, O ; Bermúdez-Humarán, LG ; Gratadoux, JJ & al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A 2015, 105:16731-6

Sokol, H ; Seksik, P ; Furet, JP ; Firmesse, O ; Nion-Larmurier, I ; Beaugerie, L & al. Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis, 2009, 15:1183-9

Martín, R ; Chain, F ; Miquel, S ; Lu, J ; Gratadoux, JJ ; Sokol, H & al. The commensal bacterium Faecalibacterium prausnitzii is protective in DNBS-induced chronic moderate and severe colitis models. Inflamm Bowel Dis 2014, 20:417-30

Sarrabayrouse, G ; Bossard, C ; Chauvin, JM ; Jarry, A ; Meurette, G ; Quévrain, E & al. CD4CD8αα lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease. PLoS Biol 2014, 12:e1001833

Martín, R ; Miquel, S ; Chain, F ; Natividad, JM ; Jury, J ; Lu, J & al. Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model. BMC Microbiol,2015,15:67

Miquel, S ; Leclerc, M ; Martin, R ; Chain, F ; Lenoir, M ; Raguideau, S & al. Identification of metabolic signatures linked to anti-inflammatory effects of Faecalibacterium prausnitzii. mBio, 2015, 6

Miquel, S ; Martín, R ; Lashermes, A ; Gillet, M ; Meleine, M ; Gelot, A & al. Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models.. Sci Rep 2016, 6:19399

Rossi, O ; van Berkel, LA ; Chain, F ; Tanweer Khan, M ; Taverne, N ; Sokol, H & al. Faecalibacterium prausnitzii A2-165 has a high capacity to induce IL-10 in human and murine dendritic cells and modulates T cell responses. Sci Rep, 2018, 6:18507

Quévrain, E ; Maubert, MA ; Michon, C ; Chain, F ; Marquant, R ; Tailhades, J & al. Identification of an anti-inflammatory protein from Faecalibacterium prausnitzii, a commensal bacterium deficient in Crohn''s disease. Gut 2016, 65:415-425

Lamas, B ; Richard, ML ; Leducq, V ; Pham, HP ; Michel, ML ; Da Costa, G & al. CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands.. Nat Med 2016, 22:598-605

Sokol, H ; Leducq, V ; Aschard, H ; Pham, HP ; Jegou, S ; Landman, C & al. Fungal microbiota dysbiosis in IBD.. Gut 2017, 66: 1039-1048

Agus, A ; Planchais, J ; Sokol, H. Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease. Cell Host Microbe 2018, 23: 716-724

Godefroy, E ; Alameddine, J ; Montassier, E ; Mathé, J ; Desfrançois-Noël, J ; Marec, N & al  T-Regulatory Cells, Which Are Decreased in Blood Samples From Patients With Inflammatory Bowel Diseases. Gastroenterology 2018, 155: 1205-1217

Natividad, JM ; Agus, A ; Planchais, J ; Lamas, B ; Jarry, AC ; Martin, R & al. Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome.. Cell Metab 2018, 28: 737-749.e4

Miani, M ; Le Naour, J ; Waeckel-Enée, E ; Verma, SC ; Straube, M ; Emond, P & al. Gut Microbiota-Stimulated Innate Lymphoid Cells Support β-Defensin 14 Expression in Pancreatic Endocrine Cells, Preventing Autoimmune Diabetes. Cell Metab, 2018, 28: 557-572.e6

Laurans, L ; Venteclef, N ; Haddad, Y ; Chajadine, M ; Alzaid, F ; Metghalchi, S & al. Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health. Nat Med, 2018: 24: 1113-1120

Alameddine, J ; Godefroy, E ; Papargyris, L ; Sarrabayrouse, G ; Tabiasco, J ; Bridonneau, C & al. Skews Human DC to Prime IL10-Producing T Cells Through TLR2/6/JNK Signaling and IL-10, IL-27, CD39, and IDO-1 Induction. Front Immunol 2019, 10:143

Aschard, H ; Laville, V ; Tchetgen, ET ; Knights, D ; Imhann, F ; Seksik, P & al. Genetic effects on the commensal microbiota in inflammatory bowel disease patients. PLoS Genet 2019, 15: e1008018

Lenoir, M ; Martín, R ; Torres-Maravilla, E ; Chadi, S ; González-Dávila, P ; Sokol, H & al. Butyrate mediates anti-inflammatory effects of  Faecalibacterium prausnitzii in intestinal epithelial cells through Dact3. Gut Microbes 2020, 12:1-16

Sokol, H ; Landman, C ; Seksik, P ; Berard, L ; Montil, M ; Nion-Larmurier, I & al. Fecal microbiota transplantation to maintain remission in Crohn''s disease: a pilot randomized controlled study. Microbiome 2020, 8:12

Lamas, B ; Hernandez-Galan, L ; Galipeau, HJ ; Constante, M ; Clarizio, A ; Jury, J & al. Aryl hydrocarbon receptor ligand production by the gut microbiota is decreased in celiac disease leading to intestinal inflammation. Sci Transl Med 2020, 12

Agus, A ; Clément, K ; Sokol, H. Gut microbiota-derived metabolites as central regulators in metabolic disorders. Gut 2020

Sokol, H ; Brot, L ; Stefanescu, C ; Auzolle, C ; Barnich, N ; Buisson, A & al. Prominence of ileal mucosa-associated microbiota to predict postoperative endoscopic recurrence in Crohn''s disease. Gut 2020, 69: 462-472

Lemoinne, S ; Kemgang, A ; Ben Belkacem, K ; Straube, M ; Jegou, S ; Corpechot, C & al. Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis. Gut 2020, 69: 92-102

Michaudel, C ; Sokol, H  The Gut Microbiota at the Service of Immunometabolism. Cell Metab. 2020, 32: 514-523

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