EXL01 is very simple in principle. EXL01 is a single strain of F. prau, rationally selected, cultivated, lyophilized, and encapsulated in a special entero-protected capsule designed to protect the bacteria and to release them in a targeted area in the lower end of the small intestines, where F. prau is naturally found.
But EXL01 was also very complex in practice to develop due to the technologies and the know-how it required. F. prau has naturally evolved over millions of years in our gut, and can, therefore, tolerate only very specific conditions characterized notably by a total absence of oxygen. Only a couple of years ago, it was still deemed impossible to cultivate F. prau in industrial conditions and in large quantities. Confident that this bacterium could make a real difference for patients, we decided anyway to take up the challenge of manufacturing such strains and, by doing so, to cross this frontier of science.
After a decade of intense R&D efforts, we have designed a one-of-a-kind production process to manufacture large-scale industrial batches of our F. prau strain, making sure that we ensured the best possible conditions that mimicked the gut environment to grow and protect the bacteria all the way from fermentation, harvesting and lyophilization to encapsulation.
The capsule that we use also incorporates specific technologies to target the desired area in the human gut where F. prau can participate to the best of its abilities in improving the regulation of the inflammation in the gut.